Different effects of 4-aminopyridine on sensory and motor fibers: pathogenesis of paresthesias.

@article{Kocsis1986DifferentEO,
  title={Different effects of 4-aminopyridine on sensory and motor fibers: pathogenesis of paresthesias.},
  author={Jeffery D Kocsis and Connie M Bowe and Stephen G. Waxman},
  journal={Neurology},
  year={1986},
  volume={36 1},
  pages={117-20}
}
Mammalian motor and sensory fibers respond differently to the potassium channel-blocking agent, 4-aminopyridine (4-AP). The action potentials of the motor fibers increase in duration after 4-AP, while the sensory fibers respond with bursts of action potentials after a single stimulus. These differences may account for the paresthesias reported by patients with multiple sclerosis following treatment with 4-AP. 

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