Different effect of the Ca(2+) sensitizers EMD 57033 and CGP 48506 on cross-bridge cycling in human myocardium.

@article{Brixius2000DifferentEO,
  title={Different effect of the Ca(2+) sensitizers EMD 57033 and CGP 48506 on cross-bridge cycling in human myocardium.},
  author={Klara Brixius and Uwe Mehlhorn and Wilhelm Bloch and Robert H. G. Schwinger},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2000},
  volume={295 3},
  pages={1284-90}
}
Ca(2+) sensitizers may be advantageous for treatment in human heart failure by increasing cardiac force without increasing the Ca(2+) transient or energy consumption. To study the mode of action of the Ca(2+) sensitizers EMD 57033 (EMD) and CGP 48506 (CGP), their influence on butanedione monoxime (BDM)-mediated depression of cross-bridge cycling was analyzed in human myocardium (explanted hearts, dilated cardiomyopathy, n = 19). In Triton X (1%)-skinned fiber preparations of left ventricular… CONTINUE READING
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