Different dynamics and pathway of disulfide bonds reduction of two human defensins, a molecular dynamics simulation study.

Abstract

Human defensins are a class of antimicrobial peptides that are crucial components of the innate immune system. Both human α defensin type 5 (HD5) and human β defensin type 3 (hBD-3) have 6 cysteine residues which form 3 pairs of disulfide bonds in oxidizing condition. Disulfide bond linking is important to the protein structure stabilization, and the… (More)
DOI: 10.1002/prot.25247

Topics

Cite this paper

@article{Zhang2017DifferentDA, title={Different dynamics and pathway of disulfide bonds reduction of two human defensins, a molecular dynamics simulation study.}, author={L. Louis Zhang}, journal={Proteins}, year={2017}, volume={85 4}, pages={665-681} }