Different domains of synaptotagmin control the choice between kiss-and-run and full fusion

@article{Wang2003DifferentDO,
  title={Different domains of synaptotagmin control the choice between kiss-and-run and full fusion},
  author={Chih-Tien Wang and J Lu and Jihong Bai and Payne Y. Chang and Thomas F J Martin and Edwin R Chapman and Meyer B Jackson},
  journal={Nature},
  year={2003},
  volume={424},
  pages={943-947}
}
Exocytosis—the release of the contents of a vesicle—proceeds by two mechanisms. Full fusion occurs when the vesicle and plasma membranes merge. Alternatively, in what is termed kiss-and-run, vesicles can release transmitter during transient contacts with the plasma membrane. Little is known at the molecular level about how the choice between these two pathways is regulated. Here we report amperometric recordings of catecholamine efflux through individual fusion pores. Transfection with… CONTINUE READING

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