Different domains of C. elegans PAR-3 are required at different times in development.

Abstract

Polarity is a fundamental cellular feature that is critical for generating cell diversity and maintaining organ functions during development. In C. elegans, the one-cell embryo is polarized via asymmetric localization of the PAR proteins, which in turn are required to establish the future anterior-posterior axis of the embryo. PAR-3, a conserved PDZ domain… (More)
DOI: 10.1016/j.ydbio.2010.05.506

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