Different cytokines induce surface lymphotoxin-alphabeta on IL-7 receptor-alpha cells that differentially engender lymph nodes and Peyer's patches.

@article{Yoshida2002DifferentCI,
  title={Different cytokines induce surface lymphotoxin-alphabeta on IL-7 receptor-alpha cells that differentially engender lymph nodes and Peyer's patches.},
  author={Hisahiro Yoshida and Asuka Naito and Jun-Ichiro Inoue and Mizuho Satoh and Sybil M Santee-Cooper and Carl F Ware and Atsushi Togawa and Satomi Nishikawa and Shin-ichi Nishikawa},
  journal={Immunity},
  year={2002},
  volume={17 6},
  pages={823-33}
}
The formation of lymph nodes (LN) and Peyer's patches (PP) can be distinguished by the requirement of RANK for LN but not IL-7R(alpha), which is essential for PP development. However, lymphotoxin-alphabeta (LT(alpha)beta) signaling is required for both organs. The cellular basis underlying this dichotomy was revealed by the finding that the fetal IL-7R(alpha)(+) population responded equally well to IL-7 and RANKL to express LT(alpha)beta. IL-7R(alpha)(+) cells harvested from TRAF6(-/-) embryos… CONTINUE READING
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