Different cytokine production and effector/memory dynamics of alpha beta+ or gamma delta+ T-cell subsets in the peripheral blood of patients with active pulmonary tuberculosis.

@article{Gioia2003DifferentCP,
  title={Different cytokine production and effector/memory dynamics of alpha beta+ or gamma delta+ T-cell subsets in the peripheral blood of patients with active pulmonary tuberculosis.},
  author={Cristiana Gioia and Chiara Agrati and Delia Goletti and Donatella Vincenti and Stefania Carrara and M Amicosante and Maria Beatrice Casarini and S. Giosu{\'e} and Giovanni Puglisi and Alfredo Francesco Rossi and Vittorio Colizzi and Leopoldo Paolo Pucillo and Fabrizio Poccia},
  journal={International journal of immunopathology and pharmacology},
  year={2003},
  volume={16 3},
  pages={247-52}
}
Immunity to M.tuberculosis (MTB) infection consists of interactions between various T-cell subsets that control the infection and prevent further reactivation. We analysed the effector/memory T-cell dynamics and cytokines production in the peripheral blood of patients with pulmonary tuberculosis (TB). We observed that the frequency of CD4+ T-cell effectors was significantly increased during active TB, confirming a major role of this T-cell subset in TB immunity. Pre-terminally differentiated… CONTINUE READING