Different contributions of ASIC channels 1a, 2, and 3 in gastrointestinal mechanosensory function.

@article{Page2005DifferentCO,
  title={Different contributions of ASIC channels 1a, 2, and 3 in gastrointestinal mechanosensory function.},
  author={Amanda J. Page and Stuart M Brierley and Chris M Martin and Margaret P. Price and Erin L Symonds and Ross Butler and John A. Wemmie and L Ashley Blackshaw},
  journal={Gut},
  year={2005},
  volume={54 10},
  pages={1408-15}
}
AIMS Members of the acid sensing ion channel (ASIC) family are strong candidates as mechanical transducers in sensory function. The authors have shown that ASIC1a has no role in skin but a clear influence in gastrointestinal mechanotransduction. Here they investigate further ASIC1a in gut mechanoreceptors, and compare its influence with ASIC2 and ASIC3. METHODS AND RESULTS Expression of ASIC1a, 2, and 3 mRNA was found in vagal (nodose) and dorsal root ganglia (DRG), and was lost in mice… CONTINUE READING

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