Different contractile effects of substance P on the intestine of mammals

  title={Different contractile effects of substance P on the intestine of mammals},
  author={Peter Holzer},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
The contractile effect of substance P was examined on the longitudinal muscle of isolated sections of the gut of cat, guinea-pig, pig, rabbit, and rat. Substance P caused contraction of all intestinal regions investigated, but there were marked qualitative and quantitative differences in the contractile responses to substance P. Low concentrations of substance P that did not cause tonic contraction (0.22–2.2 nM), increased the phasic longitudinal contractions observed in the ileum of cat, pig… CONTINUE READING

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