Different conformations of nascent polypeptides during translocation across the ER membrane


In eukaryotic cells, proteins are translocated across the ER membrane through a continuous ribosome-translocon channel. It is unclear to what extent proteins can fold already within the ribosome-translocon channel, and previous studies suggest that only a limited degree of folding (such as the formation of isolated α-helices) may be possible within the… (More)
DOI: 10.1186/1471-2121-1-3


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