Different complex formations of dentatorubral-pallidoluysian atrophy (DRPLA) protein in human and rat neurons.

Abstract

Dentatorubral-pallidoluysian atrophy (DRPLA) is caused by expansion of a glutamine repeat in DRPLA protein. Rat DRPLA protein, homologous in sequence to human DRPLA protein, was identified in rat brains. Immunoblots of human control and rat brain tissues with and without reduction show that human DRPLA protein forms more disulfide-bond complexes than rat… (More)

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