Different combinations of Notch ligands and receptors regulate V2 interneuron progenitor proliferation and V2a/V2b cell fate determination.

@article{Okigawa2014DifferentCO,
  title={Different combinations of Notch ligands and receptors regulate V2 interneuron progenitor proliferation and V2a/V2b cell fate determination.},
  author={Sayumi Okigawa and Takamasa Mizoguchi and Makoto Okano and Haruna Tanaka and Miho Isoda and Y Jiang and Maximiliano L. Suster and Shin-Ichi Higashijima and Koichi Kawakami and Motoyuki Itoh},
  journal={Developmental biology},
  year={2014},
  volume={391 2},
  pages={196-206}
}
The broad diversity of neurons is vital to neuronal functions. During vertebrate development, the spinal cord is a site of sensory and motor tasks coordinated by interneurons and the ongoing neurogenesis. In the spinal cord, V2-interneuron (V2-IN) progenitors (p2) develop into excitatory V2a-INs and inhibitory V2b-INs. The balance of these two types of interneurons requires precise control in the number and timing of their production. Here, using zebrafish embryos with altered Notch signaling… CONTINUE READING
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