Different clonal dynamics of chronic myeloid leukaemia between bone marrow and the central nervous system.

Isolated central nervous system relapse (ICNSR) is the term used to describe an extramedullary blast crisis in the central nervous system (CNS) of patients with chronic myeloid leukaemia (CML) without bone marrow (BM) involvement. Most patients with ICNSR have been treated with imatinib. It has been speculated that imatinib fails to prevent ICNSR due to its… CONTINUE READING