Different clinical characteristics of aminoglycoside-induced profound deafness with and without the 1555 A-->G mitochondrial mutation.

@article{Tono2001DifferentCC,
  title={Different clinical characteristics of aminoglycoside-induced profound deafness with and without the 1555 A-->G mitochondrial mutation.},
  author={Tetsuya Tono and Kensuke Kiyomizu and Kazunori Matsuda and Shizuo Komune and Shin-ichi Usami and Satoko Abe and Hideichi Shinkawa},
  journal={ORL; journal for oto-rhino-laryngology and its related specialties},
  year={2001},
  volume={63 1},
  pages={25-30}
}
Recent genetic studies have shown that hereditary susceptibility to aminoglycoside antibiotics is caused by the 1555 A-->G mitochondrial mutation. We found the 1555 mutation in 4 out of 68 postlingual deaf patients who were candidates for cochlear implantation. All 4 patients developed bilateral profound hearing loss following administration of aminoglycosides. The pedigree of the family shows exclusively maternal transmission of hearing impairment in each case. On comparison with neuro… CONTINUE READING
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