Different changes in cortical tumor necrosis factor-α-related pathways in schizophrenia and mood disorders

@article{Dean2013DifferentCI,
  title={Different changes in cortical tumor necrosis factor-α-related pathways in schizophrenia and mood disorders},
  author={Brian Dean and Andrew S. Gibbons and Nahed Tawadros and Lucy J Brooks and Ian Everall and Elizabeth Scarr},
  journal={Molecular Psychiatry},
  year={2013},
  volume={18},
  pages={767-773}
}
The growing body of evidence implicating tumor necrosis factor-α (TNFα) in the pathophysiology of psychiatric disorders led us to measure levels of that protein in the cortex of subjects with major depressive disorders (MDD). Having reported an increase (458%) in the levels of the transmembrane (tmTNFα), but not the soluble (sTNFα), form of the protein in Brodmann's area (BA) 46, but not 24, in people with the disorder, we decided to examine additional components of TNFα-related pathways in the… CONTINUE READING
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