Different carcinogenic process in cholangiocarcinoma cases epidemically developing among workers of a printing company in Japan.

@article{Sato2014DifferentCP,
  title={Different carcinogenic process in cholangiocarcinoma cases epidemically developing among workers of a printing company in Japan.},
  author={Yasunori Sato and Shoji Kubo and Shigekazu Takemura and Yasuhiko Sugawara and Shogo Tanaka and Masahiro Fujikawa and Akira Arimoto and Kenichi Harada and Motoko Sasaki and Yasuni Nakanuma},
  journal={International journal of clinical and experimental pathology},
  year={2014},
  volume={7 8},
  pages={4745-54}
}
Recently, cholangiocarcinoma has epidemically developed among young adult workers of a printing company in Japan. Exposure to organic solvents including 1,2-dichloropropane and/or dichloromethane is supposed to be associated with the carcinoma development. The metabolism of dichloromethane proceeds through a Theta-class glutathione S-transferase (GST) T1-1-catalyzed pathway, where its reactive intermediates have been implicated in genotoxicity and carcinogenicity. This study examined features… CONTINUE READING
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