Different biocompatibility of crystalline triamcinolone deposits on retinal cells in vitro and in vivo.

@article{Szurman2007DifferentBO,
  title={Different biocompatibility of crystalline triamcinolone deposits on retinal cells in vitro and in vivo.},
  author={Peter Szurman and Ana Sierra and Radoslaw Kaczmarek and Gesine Bettina Jaissle and Barbara Wallenfels-Thilo and Salvatore Grisanti and Matthias Lueke and K. U. Bartz-Schmidt and Martin S. Spitzer},
  journal={Experimental eye research},
  year={2007},
  volume={85 1},
  pages={44-53}
}
Epiretinal deposits of triamcinolone acetonide (TA) can be detrimental to retinal cells in vitro as several laboratory studies have shown. This contrasts with the good clinical experience of intravitreal TA use. We investigated the effect of TA crystals on retinal cells concerning the critical dose range, a potential cell recovery, the drug-tissue interaction and what protective biological factors could explain the discrepancy between in vivo and in vitro results. A human retinal pigment… CONTINUE READING

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