Different bacterial gene expression patterns and attenuated host immune responses are associated with the evolution of low-level vancomycin resistance during persistent methicillin-resistant Staphylococcus aureus bacteraemia

@article{Howden2007DifferentBG,
  title={Different bacterial gene expression patterns and attenuated host immune responses are associated with the evolution of low-level vancomycin resistance during persistent methicillin-resistant Staphylococcus aureus bacteraemia},
  author={Benjamin P Howden and Danielle J. Smith and Ashley S. Mansell and Paul D R Johnson and Peter R. B. Ward and Timothy P Stinear and John K. Davies},
  journal={BMC Microbiology},
  year={2007},
  volume={8},
  pages={39 - 39}
}
Low-level vancomycin resistance in Staphylococcus aureus (vancomycin-intermediate S. aureus (VISA) and hetero-VISA [hVISA]) emerges during persistent infection and failed vancomycin therapy. Up-regulation of genes associated with the "cell wall stimulon" and mutations in the vraSR operon have both been implicated in the development of resistance, however the molecular mechanisms of resistance are not completely understood. To further elucidate the mechanisms leading to resistance transcriptome… CONTINUE READING
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