Different approaches of impregnation for resolution of enantiomers of atenolol, propranolol and salbutamol using Cu(II)-L-amino acid complexes for ligand exchange on commercial thin layer chromatographic plates.

@article{Bhushan2010DifferentAO,
  title={Different approaches of impregnation for resolution of enantiomers of atenolol, propranolol and salbutamol using Cu(II)-L-amino acid complexes for ligand exchange on commercial thin layer chromatographic plates.},
  author={R. Bhushan and Shivani Tanwar},
  journal={Journal of chromatography. A},
  year={2010},
  volume={1217 8},
  pages={
          1395-8
        }
}
  • R. Bhushan, Shivani Tanwar
  • Published 2010
  • Chemistry, Medicine
  • Journal of chromatography. A
  • Atenolol and propranolol (the beta-blocking agents) and salbutamol (broncho- and vasodilator) were resolved into their enantiomers by adopting different modes of loading/impregnating the Cu(II) complexes of L-proline (L-Pro), L-phenylalanine (L-Phe), L-histidine (L-His), N,N-dimethyl-L-phenylalanine (N,N-Me(2)-L-Phe), and L-tryptophan (L-Trp) on commercial precoated normal phase plates. The three different approaches were (A) using the Cu(II)-L-amino acid complex as chiral mobile phase additive… CONTINUE READING
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