Different apoptotic pathways induced by zearalenone, T-2 toxin and ochratoxin A in human hepatoma cells.

@article{Bouaziz2008DifferentAP,
  title={Different apoptotic pathways induced by zearalenone, T-2 toxin and ochratoxin A in human hepatoma cells.},
  author={Chayma Bouaziz and Ossama Sharaf el dein and Emna El Golli and Salwa Abid-Essefi and Catherine Brenner and Christophe Lemaire and Hassen Bacha},
  journal={Toxicology},
  year={2008},
  volume={254 1-2},
  pages={
          19-28
        }
}
  • Chayma Bouaziz, Ossama Sharaf el dein, +4 authors Hassen Bacha
  • Published in Toxicology 2008
  • Biology, Medicine
  • Mycotoxins, secondary metabolites produced by moulds, have been shown to cause diverse toxic effects in animals and are also suspected of disease causation in humans. The present study compares the molecular mechanisms of the toxicity of zearalenone (ZEN), T-2 toxin and ochratoxin A (OTA) in human hepatoma cells HepG2. The three mycotoxins-induced a caspase-dependent mitochondrial apoptotic pathway. The mitochondrial alterations include: bax relocalisation into the mitochondrial outer membrane… CONTINUE READING

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