Different antiviral activities of IFN-alpha subtypes in human liver cell lines: synergism between IFN-alpha2 and IFN-alpha8.

@article{Yamamoto2002DifferentAA,
  title={Different antiviral activities of IFN-alpha subtypes in human liver cell lines: synergism between IFN-alpha2 and IFN-alpha8.},
  author={Shigeto Yamamoto and Hirohisa Yano and Osamu Sanou and Hakuo Ikegami and Masashi Kurimoto and Masamichi Kojiro},
  journal={Hepatology research : the official journal of the Japan Society of Hepatology},
  year={2002},
  volume={24 2},
  pages={99}
}
We have studied the antiviral activities of five recombinant interferon-alpha (IFN-alpha) subtypes, namely IFN-alpha1, -alpha2, -alpha5, -alpha8 and -alpha10, in eight human liver cancer cell lines. The relative antiviral activities, expressed in terms of the mean 50% inhibitory concentration (IC50), were different for each cell line. In general, IFN-alpha8 was the most potent, IFN-alpha2, -alpha5, and -alpha10 were intermediately active, and IFN-alpha1 was the least potent in the all cell… CONTINUE READING