Different antiproliferative effects of matuzumab and cetuximab in A431 cells are associated with persistent activity of the MAPK pathway.

@article{Meira2009DifferentAE,
  title={Different antiproliferative effects of matuzumab and cetuximab in A431 cells are associated with persistent activity of the MAPK pathway.},
  author={D{\'e}bora Dummer Meira and Isabel P N{\'o}brega and Vitor Hugo de Almeida and J{\^a}nio da Silva Moror{\'o} and Alexander Machado Cardoso and Ricardo Louro Silva and Rodolpho Mattos Albano and Carlos Gil Ferreira},
  journal={European journal of cancer},
  year={2009},
  volume={45 7},
  pages={
          1265-73
        }
}
Preclinical studies have shown the potential antitumour efficacy of monoclonal antibodies (MAbs) directed to the epidermal growth factor receptor (EGFR). In this report, we investigated the cytotoxic effects of the MAb matuzumab (EMD 72000) towards A431 cells and compared it to cetuximab. While cetuximab induced cell cycle arrest and inhibited A431 cell proliferation, matuzumab did not. Both MAbs inhibited growth factor induced EGFR, HER2 and AKT phosphorylation; however, only cetuximab… CONTINUE READING

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