Different amygdala subregions mediate valence-related and attentional effects of oxytocin in humans

@article{Gamer2010DifferentAS,
  title={Different amygdala subregions mediate valence-related and attentional effects of oxytocin in humans},
  author={Matthias Gamer and Bartosz Zurowski and Christian B{\"u}chel},
  journal={Proceedings of the National Academy of Sciences},
  year={2010},
  volume={107},
  pages={9400 - 9405}
}
The neuropeptide oxytocin enhances the processing of positive social stimuli and improves the capacity to effectively attend the eye region of conspecifics. To investigate the neural basis of these effects, we combined intranasal oxytocin administration with high-resolution functional magnetic resonance imaging in a unique emotion classification task. Emotional faces were briefly presented while controlling for the initial fixation, and measuring subsequent eye movements. Oxytocin had… 

Figures and Tables from this paper

Oxytocin Attenuates Neural Reactivity to Masked Threat Cues from the Eyes
TLDR
The results suggest that oxytocin modulates facial emotion processing at early perceptual stages prior to full evaluation of the emotional expression, which may have important implications for clinical states of social anxiety.
Oxytocin Promotes Facial Emotion Recognition and Amygdala Reactivity in Adults with Asperger Syndrome
TLDR
Intranasal administration of the neuropeptide oxytocin improved performance in a facial emotion recognition task in individuals with Asperger syndrome and was linked to increased left amygdala reactivity in response to facial stimuli and increased activity in the neural network involved in social cognition.
Oxytocin increases recognition of masked emotional faces
The effect of intranasal oxytocin on visual processing and salience of human faces
TLDR
A robust effect that intranasal OT increases the salience of human faces in binocular rivalry, such that dominance durations of faces are longer—this effect is not modulated by the facial expression.
Oxytocin Enhances the Neural Efficiency of Social Perception
TLDR
Findings suggest OT modulates early stages of social perception for socially complex information such as emotional faces relative to neutral, consistent with models suggesting OT impacts the salience of socially informative cues during processing, which leads to downstream effects in behavior.
Oxytocinergic modulation of brain activation to cues related to reproduction and attachment: Differences and commonalities during the perception of erotic and fearful social scenes.
  • C. Sauer, C. Montag, M. Reuter, P. Kirsch
  • Psychology, Biology
    International journal of psychophysiology : official journal of the International Organization of Psychophysiology
  • 2019
Oxytocin increases amygdala reactivity to threatening scenes in females
Oxytocin and Facial Emotion Recognition.
  • M. Ellenbogen
  • Psychology, Biology
    Current topics in behavioral neurosciences
  • 2018
TLDR
This chapter examines how oxytocin influences the processing of emotion in faces by reviewing intranasal administration studies of automatic processing, selective attention, and emotion recognition.
Intranasal Oxytocin Lessens the Attentional Bias to Adult Negative Faces: A Double Blind within-Subject Experiment
TLDR
Oxytocin reduces attention to negative social emotions in adults, which supports oxytocin serves to inhibit withdrawal-related social behaviour, and Oxytocin did not enhance the attentional bias toward adult happy faces.
...
...

References

SHOWING 1-10 OF 57 REFERENCES
Oxytocin Attenuates Amygdala Responses to Emotional Faces Regardless of Valence
Oxytocin Modulates Neural Circuitry for Social Cognition and Fear in Humans
TLDR
It is shown that human amygdala function is strongly modulated by oxytocin, and this results indicate a neural mechanism for the effects of Oxytocin in social cognition in the human brain and provide a methodology and rationale for exploring therapeutic strategies in disorders in which abnormal amygdala function has been implicated, such as social phobia or autism.
Regional response differences across the human amygdaloid complex during social conditioning.
TLDR
A role for the human amygdala in social learning is document and coarse regional dissociations in amygdala activity that are consistent with previous human and nonhuman animal data are revealed.
Oxytocin Increases Gaze to the Eye Region of Human Faces
Amygdala Activation Predicts Gaze toward Fearful Eyes
TLDR
Functional magnetic resonance imaging data and eye movements acquired during the evaluation of facial expressions reveal a direct role of the amygdala in reflexive gaze initiation toward fearfully widened eyes and open a window for future studies on patients with autism spectrum disorder.
A neuromodulatory role for the human amygdala in processing emotional facial expressions.
TLDR
Functional neuroimaging confirmed that the amygdala and some of its functionally connected structures mediate specific neural responses to fearful expressions and demonstrated that amygdalar responses predict expression-specific neural activity in extrastriate cortex.
Oxytocin Enhances the Encoding of Positive Social Memories in Humans
Oxytocin enhances processing of positive versus negative emotional information in healthy male volunteers
TLDR
It is suggested that oxytocin modulates emotion processing in healthy male volunteers, which may contribute to the emerging role of the neuropeptide in promoting affiliative and approach behaviours by reducing the salience of potentially ambiguous and threatening social stimuli.
...
...