Different alpha-adrenoceptors mediate migration of vascular smooth muscle cells and adventitial fibroblasts in vitro.

@article{Zhang2002DifferentAM,
  title={Different alpha-adrenoceptors mediate migration of vascular smooth muscle cells and adventitial fibroblasts in vitro.},
  author={Hua Zhang and Carie S. Facemire and Albert Joseph Banes and James E. Faber},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2002},
  volume={282 6},
  pages={H2364-70}
}
Norepinephrine directly induces growth of the vascular wall, which may involve not only proliferation of smooth muscle cells (SMCs) and adventitial fibroblasts (AFBs) but also augmentation of their migration. To test this hypothesis, growth-arrested SMCs and AFBs from rat aorta were exposed to norepinephrine. Norepinephrine caused dose-dependent migration of both cell types that was dependent on chemotaxis. In contrast, platelet-derived growth factor (PDGF)-BB, used as a positive control… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 22 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 43 references

1-Adrenoceptor stimulation directly augments growth of the injured vascular wall in vivo (Abstract)

  • C Erami, JE Faber
  • FASEB J 15:
  • 2001
Highly Influential
5 Excerpts

Cardiovascular 1-adrenoceptor subtypes: functions and signaling

  • DR Varma, Deng X-F
  • Can J Physiol Pharmacol
  • 2000
Highly Influential
4 Excerpts

Similar Papers

Loading similar papers…