Different activity regulation and subcellular localization of LIMK1 and LIMK2 during cell cycle transition.

@article{Sumi2006DifferentAR,
  title={Different activity regulation and subcellular localization of LIMK1 and LIMK2 during cell cycle transition.},
  author={Tomoyuki Sumi and Atsuko Hashigasako and Kunio Matsumoto and Toshikazu Nakamura},
  journal={Experimental cell research},
  year={2006},
  volume={312 7},
  pages={1021-30}
}
LIM kinases (LIMK1 and LIMK2) regulate actin cytoskeletal reorganization through phosphorylating and inactivating cofilin, an actin-depolymerizing factor of actin filaments. Here, we describe a detailed analysis of the cell-cycle-dependent activity of LIMK2, and a subcellular localization of LIMK1 and LIMK2. The activity of LIMK2, distinct from LIMK1, toward cofilin phosphorylation did not change in the normal cell division cycle. In contrast, LIMK2 was hyperphosphorylated and its activity was… CONTINUE READING
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