Different actions of anticonvulsant and anesthetic barbiturates revealed by use of cultured mammalian neurons.

@article{Macdonald1978DifferentAO,
  title={Different actions of anticonvulsant and anesthetic barbiturates revealed by use of cultured mammalian neurons.},
  author={Robert L Macdonald and Jeffery L. Barker},
  journal={Science},
  year={1978},
  volume={200 4343},
  pages={775-7}
}
Barbiturate anesthetics, but not anticonvulsants, abolish the spontaneous activity of cultured spinal cord neurons; directly increase membrane conductance, an effect which is suppressed by the gamma-aminobutyric acid (GABA) antagonists picrotoxin and penicillin; and are more potent than anticonvulsants in augmenting GABA and depressing glutamate responses. Barbiturate anticonvulsants abolish picrotoxin-induced convulsive activity. These results indicate qualitative and quantitative differences… CONTINUE READING

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