Different ability of clenbuterol and salbutamol to block sodium channels predicts their therapeutic use in muscle excitability disorders.

@article{Desaphy2003DifferentAO,
  title={Different ability of clenbuterol and salbutamol to block sodium channels predicts their therapeutic use in muscle excitability disorders.},
  author={J. Desaphy and S. Pierno and A. De Luca and P. Didonna and D. Camerino},
  journal={Molecular pharmacology},
  year={2003},
  volume={63 3},
  pages={
          659-70
        }
}
Activation of muscle beta(2)-adrenergic receptors successfully counteracted sarcolemma inexcitability in patients suffering from hyperkalemic periodic paralysis (HPP), a hereditary disease caused by mutations in the gene encoding the skeletal muscle sodium channel. Looking for potential modulation of these channels by beta(2)-adrenergic pathway using patch-clamp technique, we found that clenbuterol blocked sodium currents (I(Na)) in rat skeletal muscle fibers and in tsA201 cells transfected… Expand
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References

SHOWING 1-10 OF 46 REFERENCES
Gating of myotonic Na channel mutants defines the response to mexiletine and a potent derivative
  • 46
  • Highly Influential
  • PDF
Effects of propranolol and a number of its analogues on sodium channels.
  • 48
Actions of sympathomimetic amines and their antagonists on skeletal muscle.
  • 267
Anticonvulsant and sodium channel blocking activity of higher doses of clenbuterol
  • 24
Common molecular determinants of local anesthetic, antiarrhythmic, and anticonvulsant block of voltage-gated Na+ channels.
  • 424
  • PDF
Anabolic effects of clenbuterol on skeletal muscle are mediated by beta 2-adrenoceptor activation.
  • 152
Enhancement of rabbit cardiac sodium channels by beta-adrenergic stimulation.
  • 159
Partial recovery of skeletal muscle sodium channel properties in aged rats chronically treated with growth hormone or the GH-secretagogue hexarelin.
  • 16
  • PDF
Blockade by cAMP of native sodium channels of adult rat skeletal muscle fibers.
  • 12
Characterization of beta-adrenergic receptors of human skeletal muscle obtained by needle biopsy.
  • 62
...
1
2
3
4
5
...