Different Stability and Proteasome-Mediated Degradation Rate of SMN Protein Isoforms

@inproceedings{Locatelli2015DifferentSA,
  title={Different Stability and Proteasome-Mediated Degradation Rate of SMN Protein Isoforms},
  author={Denise Locatelli and Mineko Terao and Mami Kurosaki and Maria Clara Zanellati and Daniela Rita Pletto and Adele Finardi and Francesca Colciaghi and Enrico Garattini and Giorgio Stefano Battaglia and Thomas M Wishart},
  booktitle={PloS one},
  year={2015}
}
The key pathogenic steps leading to spinal muscular atrophy (SMA), a genetic disease characterized by selective motor neuron degeneration, are not fully clarified. The full-length SMN protein (FL-SMN), the main protein product of the disease gene SMN1, plays an established role in the cytoplasm in snRNP biogenesis ultimately leading to mRNA splicing within… CONTINUE READING