• DOI:10.1016/j.molbiopara.2018.07.005
Corpus ID: 51863714

Different SNPs in Fasciola hepatica P-glycoprotein from diverse Latin American populations are not associated with Triclabendazole resistance.

@article{Solana2018DifferentSI,
  title={Different SNPs in Fasciola hepatica P-glycoprotein from diverse Latin American populations are not associated with Triclabendazole resistance.},
  author={M. V. Solana and M. F. Dom{\'i}nguez and S. Scarcella and Santiago Rad{\'i}o and P. Smircich and S. Fern{\'a}ndez and H. Solana and J. Tort},
  journal={Molecular and biochemical parasitology},
  year={2018},
  volume={224},
  pages={
          57-60
        }
}

M. V. Solana, M. F. Domínguez, +5 authors J. Tort

Published 2018

Biology, Medicine

Molecular and biochemical parasitology

The use of Triclabendazole for controlling fasciolosis is compromised by increased drug resistance affecting livestock and humans. Although the mode of action of TCBZ is still unknown, putative candidates and markers of resistance have been advanced. A single nucleotide polymorphism (T687 G) in F. hepatica PGP was proposed as marker of resistance in a small scale study of European susceptible and resistant flukes, but the association was not found in Australian samples. The T687 G SNP was… CONTINUE READING

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