Different Roles of Mast Cells in Obesity and Diabetes: Lessons from Experimental Animals and Humans

@article{Shi2012DifferentRO,
  title={Different Roles of Mast Cells in Obesity and Diabetes: Lessons from Experimental Animals and Humans},
  author={M. Y. Shi and G. Shi},
  journal={Frontiers in Immunology},
  year={2012},
  volume={3}
}
Mast cells (MCs) play an important role in allergic hyperresponsiveness and in defending microorganism infections. Recent studies of experimental animals and humans have suggested that MCs participate in obesity and diabetes. MC distribution and activities in adipose tissues may vary, depending on the locations of different adipose tissues. In addition to releasing inflammatory mediators to affect adipose tissue extracellular matrix remodeling and to promote inflammatory cell recruitment and… Expand
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