Different Roles for Tet1 and Tet2 Proteins in Reprogramming-Mediated Erasure of Imprints Induced by EGC Fusion

@inproceedings{Piccolo2013DifferentRF,
  title={Different Roles for Tet1 and Tet2 Proteins in Reprogramming-Mediated Erasure of Imprints Induced by EGC Fusion},
  author={Francesco Piccolo and Hakan Bagci and Karen E. Brown and David Landeira and Jorge Soza-Ried and Amelie Feytout and Dylan Mooijman and Petra Hajkova and Harry G. Leitch and Takashi Tada and Skirmantas Kriaucionis and Meelad M. Dawlaty and Rudolf Jaenisch and Matthias Merkenschlager and Amanda G Fisher},
  booktitle={Molecular cell},
  year={2013}
}
Genomic imprinting directs the allele-specific marking and expression of loci according to their parental origin. Differential DNA methylation at imprinted control regions (ICRs) is established in gametes and, although largely preserved through development, can be experimentally reset by fusing somatic cells with embryonic germ cell (EGC) lines. Here, we show that the Ten-Eleven Translocation proteins Tet1 and Tet2 participate in the efficient erasure of imprints in this model system. The… CONTINUE READING
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