Different Plk1 functions show distinct dependencies on Polo-Box domain-mediated targeting.

@article{Hanisch2006DifferentPF,
  title={Different Plk1 functions show distinct dependencies on Polo-Box domain-mediated targeting.},
  author={Anja Hanisch and Anja Wehner and Erich A. Nigg and Herman H W Sillj{\'e}},
  journal={Molecular biology of the cell},
  year={2006},
  volume={17 1},
  pages={
          448-59
        }
}
Polo-like kinase 1 (Plk1) has multiple important functions during M-phase progression. In addition to a catalytic domain, Plk1 possesses a phosphopeptide-binding motif, the polo-box domain (PBD), which is required for proper localization. Here, we have explored the importance of correct Plk1 subcellular targeting for its mitotic functions. We either displaced endogenous Plk1 through overexpression of the PBD or introduced the catalytic domain of Plk1, lacking the PBD, into Plk1-depleted cells… CONTINUE READING
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