Different Munc18 proteins mediate baseline and stimulated airway mucin secretion.

@article{Jaramillo2019DifferentMP,
  title={Different Munc18 proteins mediate baseline and stimulated airway mucin secretion.},
  author={Ana M Jaramillo and Lucia Piccotti and Walter V Velasco and Anna Sofia Huerta Delgado and Zoulikha Azzegagh and Felicity S Chung and Usman I Nazeer and Junaid Haris Farooq and Joshua M. Brenner and Jan Parker-Thornburg and Brenton L. Scott and Christopher M Evans and Roberto Adachi and Alan Richard Burns and Silvia M. Kreda and Michael J Tuvim and Burton F Dickey},
  journal={JCI insight},
  year={2019}
}
Airway mucin secretion is necessary for ciliary clearance of inhaled particles and pathogens, but can be detrimental in pathologies such as asthma and cystic fibrosis. Exocytosis in mammals requires a Munc18 scaffolding protein, and airway secretory cells express all three Munc18 isoforms. Using conditional airway epithelial deletant mice, we found that Munc18a has the major role in baseline mucin secretion, Munc18b has the major role in stimulated mucin secretion, and Munc18c does not function… CONTINUE READING

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