Different MicroRNA Profiles in Chronic Epilepsy Versus Acute Seizure Mouse Models

  title={Different MicroRNA Profiles in Chronic Epilepsy Versus Acute Seizure Mouse Models},
  author={Anita Kretschmann and B{\'e}n{\'e}dicte Danis and Lidija Andonovic and Khalid Abnaof and Marijke van Rikxoort and Franziska Siegel and Manuela Mazzuferi and Patrice Godard and Etienne Hanon and Holger Fr{\"o}hlich and Rafal M Kaminski and Patrik Foerch and Alexander Pfeifer},
  booktitle={Journal of Molecular Neuroscience},
Epilepsy affects around 50 million people worldwide, and in about 65 % of patients, the etiology of disease is unknown. MicroRNAs are small non-coding RNAs that have been suggested to play a role in the pathophysiology of epilepsy. Here, we compared microRNA expression patterns in the hippocampus using two chronic models of epilepsy characterised by recurrent spontaneous seizures (pilocarpine and self-sustained status epilepticus (SSSE)) and an acute 6-Hz seizure model. The vast majority of… CONTINUE READING
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