Different Mechanisms in Formation and Prevention of Indomethacin-induced Gastric Ulcers

@article{Suleyman2009DifferentMI,
  title={Different Mechanisms in Formation and Prevention of Indomethacin-induced Gastric Ulcers},
  author={Halis Suleyman and Abdulmecit Albayrak and Mehmet Bilici and Elif Cadirci and Zekai Halici},
  journal={Inflammation},
  year={2009},
  volume={33},
  pages={224-234}
}
Indomethacin is an indol derivative, non-steroidal, anti-inflammatory drug with anti-inflammatory, analgesic, and antipyretic effects. Indomethacin became the first-choice drug to produce an experimental ulcer model as a result of having a higher ulcerogenic potential than other non-steroidal anti-inflammatory drugs (NSAIDs). There have been several conflicting reports about the ulcerogenic mechanism of indomethacin; the mechanism is still unclear. It has been suggested that indomethacin… CONTINUE READING
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