Different HLA class II associations in ulcerative colitis patients with and without primary sclerosing cholangitis

@article{Karlsen2007DifferentHC,
  title={Different HLA class II associations in ulcerative colitis patients with and without primary sclerosing cholangitis},
  author={Tom H. Karlsen and Kirsten Muri Boberg and Morten Harald Vatn and Annika Bergquist and Jochen Hampe and Erik Schrumpf and Erik Thorsby and Stefan Schreiber and Benedicte Alexandra Lie},
  journal={Genes and Immunity},
  year={2007},
  volume={8},
  pages={275-278}
}
Approximately 80% of patients with primary sclerosing cholangitis (PSC) of Northern European origin have inflammatory bowel disease (IBD), the majority ulcerative colitis (UC). An inherent problem in interpreting positive findings in genetic association studies of PSC is thus to distinguish between factors associated with hepatobiliary versus intestinal pathology. We aimed to clarify to what extent human leukocyte antigen (HLA) class II associations in UC patients with and without PSC differ… CONTINUE READING
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