Different Faces of the Heme-Heme Oxygenase System in Inflammation

  title={Different Faces of the Heme-Heme Oxygenase System in Inflammation},
  author={Frank A.D.T.G. Wagener and Hans-Dieter Volk and Dean Willis and Nader G. Abraham and Miguel P. Soares and Gosse J. Adema and Carl G. Figdor},
  journal={Pharmacological Reviews},
  pages={551 - 571}
The heme-heme oxygenase system has recently been recognized to possess important regulatory properties. It is tightly involved in both physiological as well as pathophysiological processes, such as cytoprotection, apoptosis, and inflammation. Heme functions as a double-edged sword. In moderate quantities and bound to protein, it forms an essential element for various biological processes, but when unleashed in large amounts, it can become toxic by mediating oxidative stress and inflammation… 

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