Different Effects of Exercise on Plasma Concentrations of Nebivolol, Bisoprolol and Carvedilol

@article{Stoschitzky2004DifferentEO,
  title={Different Effects of Exercise on Plasma Concentrations of Nebivolol, Bisoprolol and Carvedilol},
  author={Kurt Stoschitzky and Gergana Stoschitzky and Werner Klein and Frank M{\"u}ller and Karl Ulrich Buehring and G{\"u}nther Lamprecht and Wolfgang Lindner},
  journal={Cardiovascular Drugs and Therapy},
  year={2004},
  volume={18},
  pages={135-138}
}
Background: In-vitro studies have shown that beta-blockers are taken up into and released from adrenergic cells together with epinephrine and norepinephrine. Consequently, studies in humans revealed an increase in plasma concentrations of propranolol and atenolol, whereas those of carvedilol were not affected by physical exercise. However, nebivolol and bisoprolol never were investigated on this issue. Methods: Ten healthy males received oral doses of 5 mg nebivolol, 5 mg bisoprolol, and 50 mg… CONTINUE READING

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