Different Domains of the RNA Polymerase of Infectious Bursal Disease Virus Contribute to Virulence

Abstract

BACKGROUND Infectious bursal disease virus (IBDV) is a pathogen of worldwide significance to the poultry industry. IBDV has a bi-segmented double-stranded RNA genome. Segments A and B encode the capsid, ribonucleoprotein and non-structural proteins, or the virus polymerase (RdRp), respectively. Since the late eighties, very virulent (vv) IBDV strains have… (More)
DOI: 10.1371/journal.pone.0028064

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