Different Divalent Cations Alter the Kinetics and Fidelity of DNA Polymerases.

@article{Vashishtha2016DifferentDC,
  title={Different Divalent Cations Alter the Kinetics and Fidelity of DNA Polymerases.},
  author={Ashwani Kumar Vashishtha and Jimin Wang and William H. Konigsberg},
  journal={The Journal of biological chemistry},
  year={2016},
  volume={291 40},
  pages={
          20869-20875
        }
}
Divalent metal ions are essential components of DNA polymerases both for catalysis of the nucleotidyl transfer reaction and for base excision. They occupy two sites, A and B, for DNA synthesis. Recently, a third metal ion was shown to be essential for phosphoryl transfer reaction. The metal ion in the A site is coordinated by the carboxylate of two highly conserved acidic residues, water molecules, and the 3'-hydroxyl group of the primer so that the A metal is in an octahedral complex. Its… CONTINUE READING
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