Different Contributions of the Human Amygdala and Ventromedial Prefrontal Cortex to Decision-Making

  title={Different Contributions of the Human Amygdala and Ventromedial Prefrontal Cortex to Decision-Making},
  author={A. Bechara and H. Damasio and A. Damasio and G. P. Lee},
  journal={The Journal of Neuroscience},
  pages={5473 - 5481}
  • A. Bechara, H. Damasio, +1 author G. P. Lee
  • Published 1999
  • Psychology, Medicine
  • The Journal of Neuroscience
  • The somatic marker hypothesis proposes that decision-making is a process that depends on emotion. Studies have shown that damage of the ventromedial prefrontal (VMF) cortex precludes the ability to use somatic (emotional) signals that are necessary for guiding decisions in the advantageous direction. However, given the role of the amygdala in emotional processing, we asked whether amygdala damage also would interfere with decision-making. Furthermore, we asked whether there might be a… CONTINUE READING
    1,799 Citations

    Figures and Topics from this paper

    Paper Mentions

    Observational Clinical Trial
    The purpose of this study is to increase researchers understanding of the biological basis of generalized anxiety disorder and social anxiety disorder. They will investigate how the… Expand
    ConditionsAnxiety Disorders
    The amygdala and decision-making
    • 111
    The role of ventromedial prefrontal cortex in decision making: judgment under uncertainty or judgment per se?
    • 274
    • PDF
    Contributions of the prefrontal cortex to the neural basis of human decision making
    • D. Krawczyk
    • Psychology, Medicine
    • Neuroscience & Biobehavioral Reviews
    • 2002
    • 455
    • PDF
    Risk-Sensitive Decision-Making in Patients with Posterior Parietal and Ventromedial Prefrontal Cortex Injury
    • 95
    • PDF
    Dissociable Roles for the Basolateral Amygdala and Orbitofrontal Cortex in Decision-Making under Risk of Punishment
    • 74
    • Highly Influenced
    • PDF
    Using the Amygdala in decision making
    Cortico-limbic-striatal circuits subserving different forms of cost-benefit decision making
    • 269
    • Highly Influenced
    • PDF
    Mental time travel, somatic markers and “myopia for the future”
    • 16
    • Highly Influenced


    Dissociation Of Working Memory from Decision Making within the Human Prefrontal Cortex
    • 998
    • PDF
    The somatic marker hypothesis and the possible functions of the prefrontal cortex.
    • A. Damasio
    • Psychology, Medicine
    • Philosophical transactions of the Royal Society of London. Series B, Biological sciences
    • 1996
    • 2,265
    • PDF
    Insensitivity to future consequences following damage to human prefrontal cortex
    • 4,962
    • PDF
    Failure to respond autonomically to anticipated future outcomes following damage to prefrontal cortex.
    • 1,095
    • PDF
    Neuropsychological correlates of bilateral amygdala damage.
    • 194
    • Highly Influential
    Preserved crossmodal association following bilateral amygdalotomy in man.
    • 19
    Human Amygdala Activation during Conditioned Fear Acquisition and Extinction: a Mixed-Trial fMRI Study
    • 1,316
    • PDF
    Individuals with sociopathic behavior caused by frontal damage fail to respond autonomically to social stimuli
    • 1,164
    Differential contribution of dorsal and ventral medial prefrontal cortex to the acquisition and extinction of conditioned fear in rats.
    • 692
    • PDF