Different Ca2+ releasing action of caffeine and depolarisation in skeletal muscle fibres of the rat.

@article{Lamb2001DifferentCR,
  title={Different Ca2+ releasing action of caffeine and depolarisation in skeletal muscle fibres of the rat.},
  author={Graham D. Lamb and Mauro Cellini and D George Stephenson},
  journal={The Journal of physiology},
  year={2001},
  volume={531 Pt 3},
  pages={715-28}
}
1. The relative abilities of caffeine and transverse tubular (T-) system depolarisation to induce Ca2+ release in mammalian skeletal muscle were compared in mechanically skinned fibres of the rat, in order to determine whether normal excitation-contraction (E-C) coupling is achieved by up-regulating the Ca2+-induced Ca2+ release process, as caffeine is known to do. 2. Caffeine triggered Ca2+ release in soleus (slow-twitch) fibres at much lower concentrations than in extensor digitorum longus… CONTINUE READING

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