Different CD40-mediated signaling events require distinct CD40 structural features.

@article{Hostager1996DifferentCS,
  title={Different CD40-mediated signaling events require distinct CD40 structural features.},
  author={Bruce S. Hostager and Y Hsing and Douglas E. Harms and Gail A Bishop},
  journal={Journal of immunology},
  year={1996},
  volume={157 3},
  pages={1047-53}
}
Signals delivered to B cells through CD40 are critical to the development of humoral immune responses. In this study we characterize regions of the 62-amino acid cytoplasmic domain of human CD40 (hCD40) that are essential for signal transduction and examine the functional consequences of mutations in these regions. A panel of mutant hCD40 molecules was stably expressed in mouse B cell lines and tested for its ability to stimulate Ab secretion, homotypic adhesion, and increased surface… CONTINUE READING