Different Apoptotic Pathways Activated by Oxaliplatin in Primary Astrocytes vs. Colo-Rectal Cancer Cells

Abstract

Oxaliplatin-based chemotherapy improves the outcomes of metastatic colorectal cancer patients. Its most significant and dose-limiting side effect is the development of a neuropathic syndrome. The mechanism of the neurotoxicity is unclear. The limited knowledge about differences existing between neurotoxic and antitumor effects hinders the discovery of… (More)
DOI: 10.3390/ijms16035386

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@inproceedings{Zanardelli2015DifferentAP, title={Different Apoptotic Pathways Activated by Oxaliplatin in Primary Astrocytes vs. Colo-Rectal Cancer Cells}, author={Matteo Zanardelli and Laura Micheli and Raffaella Nicolai and Paola Failli and Carla Ghelardini and Lorenzo Di Cesare Mannelli}, booktitle={International journal of molecular sciences}, year={2015} }