Different β-adrenoceptor subtypes coupling to cAMP or NO/cGMP pathways: implications in the relaxant response of rat conductance and resistance vessels.

@article{Flacco2013DifferentS,
  title={Different β-adrenoceptor subtypes coupling to cAMP or NO/cGMP pathways: implications in the relaxant response of rat conductance and resistance vessels.},
  author={Nicla Flacco and Vanessa Segura and Miguel P{\'e}rez-Aso and Santiago Estrada and Jon Seller and Francesc Jim{\'e}nez-Altay{\'o} and Mar{\'i}a Antonia Noguera and Pilar D'Ocon and Eduardo A. Mart{\'i}nez Vila and Mar{\'i}a Dolores Ivorra},
  journal={British journal of pharmacology},
  year={2013},
  volume={169 2},
  pages={
          413-25
        }
}
BACKGROUND AND PURPOSE To analyse the relative contribution of β1 -, β2 - and β3 -adrenoceptors (Adrb) to vasodilatation in conductance and resistance vessels, assessing the role of cAMP and/or NO/cGMP signalling pathways. EXPERIMENTAL APPROACH Rat mesenteric resistance artery (MRA) and aorta were used to analyse the Adrb expression by real-time-PCR and immunohistochemistry, and for the pharmacological characterization of Adrb-mediated activity by wire myography and tissue nucleotide… CONTINUE READING
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