Differences in vascular effects and removal of endothelin-1 in human lung, brain, and skeletal muscle.

@article{Weitzberg1993DifferencesIV,
  title={Differences in vascular effects and removal of endothelin-1 in human lung, brain, and skeletal muscle.},
  author={Eddie Weitzberg and Gunvor Ahlborg and Jan. M. Lundberg},
  journal={Clinical physiology},
  year={1993},
  volume={13 6},
  pages={
          653-62
        }
}
To investigate the effects and elimination of endothelin-1 in humans, an intravenous infusion of endothelin-1 (ET-1) (4 pmol kg-1 min-1 for 20 min) was given to 10 healthy volunteers. Arterial plasma endothelin-1 like immunoreactivity (ET-1-LI) increased eleven-fold. The fractional extraction of ET-1-LI was 41% and 30% across the pulmonary and skeletal muscle vascular beds, respectively. The lung eliminated almost half of the administered ET-1. No fractional extraction was found in the cerebral… CONTINUE READING
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