Differences in transient outward currents of feline endocardial and epicardial myocytes.

  title={Differences in transient outward currents of feline endocardial and epicardial myocytes.},
  author={Tetsushi Furukawa and Robert Jerome Myerburg and Naohiro Furukawa and Arthur L. Bassett and Shoji Kimura},
  journal={Circulation research},
  volume={67 5},
Whole-cell voltage-clamp experiments were performed on enzymatically dissociated single ventricular myocytes harvested from feline endocardial and epicardial surfaces. The studies were designed to test the hypothesis that the differences in the amplitude of transient outward current (Ito) contribute to the difference in action potential configuration between endocardial and epicardial myocytes. In the control state, action potentials recorded from epicardial cells demonstrated a prominent notch… CONTINUE READING


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