Differences in the toxicity and metabolism of the 2-nitroimidazole misonidazole (Ro-07-0582) in HeLa and Chinese hamster ovary cells.

@article{Taylor1978DifferencesIT,
  title={Differences in the toxicity and metabolism of the 2-nitroimidazole misonidazole (Ro-07-0582) in HeLa and Chinese hamster ovary cells.},
  author={Yvonne C. Taylor and A. Michael Rauth},
  journal={Cancer research},
  year={1978},
  volume={38 9},
  pages={2745-52}
}
The 2.nitroimidazolemisonidazole(Ro-07-0582)is a hy poxic cell radiosensitizer currently undergoing clinical investigation.In additionto its radiosensitizingabilities,it showsan Increasedtoxicitytowardhypoxiccomparedto aerobic cells. Human HeLa cells are 2 to 3 times more sensitive to misonidazole in terms of the time required to reduce survival to 0.1% after hypoxic incubations in 5 mis drugthan are Chinese hamsterovary cells. The basis of thisdifferencein sensitivitywas investigatedwiththe… CONTINUE READING

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