Differences in the substrate binding sites of murine and human proteinase 3 and neutrophil elastase.

@article{Hajjar2007DifferencesIT,
  title={Differences in the substrate binding sites of murine and human proteinase 3 and neutrophil elastase.},
  author={Eric Hajjar and Brice Korkmaz and Nathalie Reuter},
  journal={FEBS letters},
  year={2007},
  volume={581 29},
  pages={5685-90}
}
Understanding the differences between murine (m) and human (h) proteinase 3 (PR3) and neutrophil elastase (NE) is crucial for the interpretation of in vivo studies of inflammatory processes. We built structural models of mPR3 and mNE and analyzed their surface properties. We performed molecular dynamics (MD) simulations on several enzyme-peptide complexes… CONTINUE READING