Differences in the regulation of microtubule dynamics by microtubule-associated proteins MAP1B and MAP2.

@article{Vandecandelaere1996DifferencesIT,
  title={Differences in the regulation of microtubule dynamics by microtubule-associated proteins MAP1B and MAP2.},
  author={A Vandecandelaere and Barbara Pedrotti and Michelle A. Utton and Rosaleen Ann Calvert and Peter M. Bayley},
  journal={Cell motility and the cytoskeleton},
  year={1996},
  volume={35 2},
  pages={134-46}
}
The regulation of microtubule dynamics in vitro by microtubule-associated proteins (MAPs) was examined, using purified porcine MAP1B and MAP2. MAP1B has a significantly smaller effect on the observed critical concentration for microtubule assembly than MAP2. Assembly is faster in the presence of either MAP, and the resulting microtubules are shorter, indicating that nucleation is substantially promoted by the MAPs. Both MAPs stabilise the microtubule lattice as observed from podophyllotoxin… CONTINUE READING

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